The article was just linked on Facebook:
It describes how mutations that lead to the same enzyme can nevertheless lead to cell damage. This was explicitly demonstrated here in yeast cells. However, the authors assume that the effects are similar in other cells/organisms. This would also refute the statement made by some Fabry specialists that mutations such as D313Y or A143T have no effect. We are curious and will also follow this topic. The literature research page will be supplemented accordingly…